SAMe helps maintain stable mood and joint function without side effects. In addition, SAMe has multiple mechanisms of action that are used throughout the body, especially in the liver, which help maintain liver health. Largely known for its effects on optimal mood, SAMe has also shown benefits for the liver, brain, and joints.
Benefits at a glance:
Helps maintain stable mood
Helps maintain liver health
Helps maintain healthy joint function
SAMe is an amino acid derivative normally synthesized in the body that may become depleted with sickness or age. Supplementing with SAMe plus folate, trimethylglycine (TMG or betaine), vitamins B6 and B12 appears to be an effective way to overcome this deficiency.
SAMe is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones, nucleic acids, proteins, and phospholipids, and .
SAMe is used by the body in three important pathways:
Methylation (contributing methyl groups to activate certain molecules)
The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.)
Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals)
ICaution: SAMe should not be taken by those diagnosed with bipolar disorder.